update range to 10000 bp
locus tag: FAM13496-i1-1.1_000880 genome: FAM13496-i1-1.1
species: Streptococcus thermophilus taxid: 1308

Annotations

Type Name Description Pathways
KEGG reaction
 R05071 (S)-2-Acetolactate methylmutase; (S)-2-Acetolactate <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid kornec00290kornec01100kornec01110kornec01210kornec01230
KEGG reaction
 R05069 (S)-2-Aceto-2-hydroxybutanoate:NADP+ oxidoreductase (isomerizing); (S)-2-Aceto-2-hydroxybutanoate <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate kornec00290kornec01100kornec01110kornec01210kornec01230
KEGG reaction
 R05068 (R)-2,3-Dihydroxy-3-methylpentanoate:NADP+ oxidoreductase (isomerizing); (R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+ kornec00290kornec01100kornec01110kornec01210kornec01230
KEGG reaction
 R04440 (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing); (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid + NADPH + H+ kornec00290kornec01100kornec01110kornec01210kornec01230
KEGG reaction
 R04439 (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing); (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> (S)-2-Acetolactate + NADPH + H+ kornec00770kornec01100
KEGG reaction
 R03051 2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing); 2-Acetolactate + NADPH + H+ <=> 2,3-Dihydroxy-3-methylbutanoate + NADP+
Ortholog
 N0.HOG0001898 ketol-acid reductoisomerase
Gene Product
 ketol-acid reductoisomerase
KEGG gene
 K00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] kornec00290kornec00770kornec01100kornec01110kornec01210kornec01230
Gene Code
 ilvC
Eggnog Protein
 EP:ilvC
Eggnog Ortholog
 EO:COG0059
Eggnog Description
 ED:Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2
EC Number
 EC:1.1.1.86 ketol-acid reductoisomerase (NADP+); dihydroxyisovalerate dehydrogenase (isomerizing); acetohydroxy acid isomeroreductase; ketol acid reductoisomerase; alpha-keto-beta-hydroxylacyl reductoisomerase; 2-hydroxy-3-keto acid reductoisomerase; acetohydroxy acid reductoisomerase; acetolactate reductoisomerase; dihydroxyisovalerate (isomerizing) dehydrogenase; isomeroreductase; reductoisomerase; ketol-acid reductoisomerase; (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) kornec00290kornec00770kornec01100kornec01110

Occurs in the following pathway maps:

Pathway Description
kornec00290 Valine, leucine and isoleucine biosynthesis
kornec00770 Pantothenate and CoA biosynthesis
kornec01100 Metabolic pathways
kornec01110 Biosynthesis of secondary metabolites
kornec01210 2-Oxocarboxylic acid metabolism
kornec01230 Biosynthesis of amino acids

Sequences

Nucleotide sequence (GC-content: 39.9 %):

ATGGCAGTTCAAATGGAATATGAAAAAGACGTAAAAGTACCAGCACTTGATGGTAAAAAAATCGCCGTTATCGGTTACGGTTCACAAGGTCACGCTCACTCACAAAACTTGCGTGATACAGGTCACGATGTTATCATCGGTGTTCGTCCAGGTAAATCATTTGATAAAGCTAAAGAAGATGGTTTTGATACTTACACAGTAGCAGAAGCAACTAAATTGGCTGATGTTATCATGATTTTGGCTCCAGACGAAATCCAACAAGAACTTTACGAAGCAGAAATCGCTCCAAATCTTGAAGCTGGTAACGCTGTTGGTTTTGCTCACGGTTTCAACATCCACTTTGAATTTATTAAAGTACCAGCAGATGTTGATGTATTTATGTGTGCACCTAAAGGACCAGGTCACTTGGTACGTCGTACATTTGAAGAAGGTTTTGGTGTACCTGCCCTTTACGCAGTATACCAAGATGCCACAGGTAACGCTAAAGACATCGCTATGGACTGGTGTAAAGGTATTGGTGCAGCACGTGTAGGTCTTCTTGAAACAACATACAAAGAAGAAACTGAAGAAGATTTGTTTGGTGAACAAGCAGTTCTTTGTGGTGGTTTGACTGCCCTTATCGAAACTGGTTTTGAAGTCTTGACTGAAGCTGGATATGCACCAGAATTGGCTTACTTTGAAGTACTTCACGAAATGAAATTAATCGTTGACTTGATTTACGAAGGTGGATTCAAGAAAATGCGTCAATCAATTTCTAACACTGCTGAATTCGGTGACTATGTATCAGGTCCACGTGTTATCACTGAACAAGTTAAAGAAAACATGAAAGCAGTTCTTGCTGATATCCAAAATGGTAAATTCGCTAATGACTTCGTTAACGACTACAAAGCTGGACGTCCAAAACTTACTGCTTACCGTGAAGAAGCTGCTAACCTTGAAATCGAAAAAGTTGGTGCTGAATTGCGTAAAGCAATGCCATTCGTTGGTCAAAACGACGATGATGCATTCAAAATCTATAACTAA

Protein sequence:

MAVQMEYEKDVKVPALDGKKIAVIGYGSQGHAHSQNLRDTGHDVIIGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKDIAMDWCKGIGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIETGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEFGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKLTAYREEAANLEIEKVGAELRKAMPFVGQNDDDAFKIYN

GenBank Info

gene - ilvC
locus_tag - FAM13496-i1-1.1_000880
EC_number - 1.1.1.86
inference - COORDINATES: similar to AA sequence:RefSeq:WP_003010246.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - ketol-acid reductoisomerase
protein_id - extdb:FAM13496-i1-1.1_000880

Gene Locus

Located on scaffold FAM13496-i1-1_scf10

FAM13496-i1-1.1_000879
FAM13496-i1-1.1_000881