update range to 10000 bp
locus tag: FAM13496-i1-1.1_001180 genome: FAM13496-i1-1.1
species: Streptococcus thermophilus taxid: 1308

Annotations

Type Name Description Pathways
Gene Product
 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase
KEGG reaction
 R04617 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate:D-alanyl-D-alanine ligase(ADP-forming); ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + D-Alanyl-D-alanine <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine kornec00300kornec00550kornec01100
KEGG reaction
 R04573 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:alanyl-D-alanine ligase (ADP-forming); ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-Alanyl-D-alanine <=> ADP + Orthophosphate + UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) kornec00550kornec01100
Ortholog
 N0.HOG0001422 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KEGG gene
 K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] kornec00300kornec00550kornec01100kornec01502
Eggnog Protein
 EP:murF
Eggnog Ortholog
 EO:COG0770
Eggnog Description
 ED:Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide
EC Number
 EC:6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase; MurF synthetase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase; UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase; uridine diphosphoacetylmuramoylpentapeptide synthetase; UDPacetylmuramoylpentapeptide synthetase; UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase kornec00300kornec00550kornec01100

Occurs in the following pathway maps:

Pathway Description
kornec00300 Lysine biosynthesis
kornec00550 Peptidoglycan biosynthesis
kornec01100 Metabolic pathways
kornec01502 Vancomycin resistance

Sequences

Nucleotide sequence (GC-content: 43.2 %):

ATGAAACTGACACTCCATGAAATTGCCAAGGTTGTTGGTGCTAAAAATGATGTCACTGCCTATAAAGATGTCGCCCTAAACCAGATTGAATTTGACAGCCGTAAGATCACAGCGGGGGATCTCTTTTTGCCGCTCAAAGGTGCGCGTGATGGGCATGATTTTATCCAAACAGCCTTTGACAACGGTGCTATAGCGACATTCACAGAAAAAGAATTACCGGCTGATCAAGCCCACATCCTAGTCGATGACGCTCTTGAAGCCTTCCAAGAACTAGCTGCCTACTATCTTGAAAAGACTGGTGTTGATGTTATTGCTGTGACTGGTTCTAACGGTAAGACAACCACCAAGGACATGATTCATGACATTTTGGCAACGACCTACCGCACTTATAAGACACAAGGCAATTACAACAATGAGATTGGTCTTCCTTATACAGCCCTCCACATGCCTGATGATACGGAGAAAATTGTCCTTGAGATGGGGCAAGACCATATGGGAGATATTCATCTCTTGTCAAACTTGGCTAAGCCAAAAACAGCCGTTGTTACCTTAATCGGAGAAGCTCACTTGGAATTCTTCGGTAGCCGTGACAAGATTGCTCAAGGTAAAATGCAAATGCAAGACGGTATGCCTGATGGTAGTCTCTTGCTTGTGCCATGTGATCCAATCGTTGATCCTTTCTTGCCAAGCAATCTTGAAGTGGTACGCTTTGGAGATGGTGCAGAGCTTACAGTCTCTGAGTTGACGGAATACAAGGATCATCTTACCTTTTCAACAAAGTTCCTCGACGGACAAGTTACCTTGCCAGTCACTGGAAAATACAATGCCACAAATGCCATGGTTGCTGCCTATGTCGCAAAACACTTGGGTGTAACTGAGGAAAATATCCTCTCAGCTCTTGCTAACTTGCAACTCACAAAAAACCGTACCGAATGGAAAAAAGCGGCTAATGGAGCGGATATTCTTTCTGACGTCTACAATGCCAATCCAACAGCTATGAAGCTCGTTTTGGAGACCTTCTCAGCCATTCCTAAGAATGAAGGAGGCAAGAAAATCGCTGTCCTAGCTGATATGAAAGAACTCGGTGAACAGTCTGTACAACTTCATACACAGATGATTTTAAGCCTGACACCAGATGCTATTGATACGGTGATTTTCTATGGTGAAGACATTGCAGAATTGTCACAACTTGCCAGTCAAATGTTCCCACTTGGTCATGTTTATTATTTCAAGAAGACATCTGATGAAGACCAATTTGATGCTATGGTCAAACAAATCAAAGAAAGTCTAGGCGAATACGATCAAATCTTGCTTAAGGGCTCTAACTCTATGAACCTAGCCAAGGTTGTGCAAGAACTCCAAGCTAAGGATTAA

Protein sequence:

MKLTLHEIAKVVGAKNDVTAYKDVALNQIEFDSRKITAGDLFLPLKGARDGHDFIQTAFDNGAIATFTEKELPADQAHILVDDALEAFQELAAYYLEKTGVDVIAVTGSNGKTTTKDMIHDILATTYRTYKTQGNYNNEIGLPYTALHMPDDTEKIVLEMGQDHMGDIHLLSNLAKPKTAVVTLIGEAHLEFFGSRDKIAQGKMQMQDGMPDGSLLLVPCDPIVDPFLPSNLEVVRFGDGAELTVSELTEYKDHLTFSTKFLDGQVTLPVTGKYNATNAMVAAYVAKHLGVTEENILSALANLQLTKNRTEWKKAANGADILSDVYNANPTAMKLVLETFSAIPKNEGGKKIAVLADMKELGEQSVQLHTQMILSLTPDAIDTVIFYGEDIAELSQLASQMFPLGHVYYFKKTSDEDQFDAMVKQIKESLGEYDQILLKGSNSMNLAKVVQELQAKD

GenBank Info

locus_tag - FAM13496-i1-1.1_001180
inference - COORDINATES: similar to AA sequence:RefSeq:WP_014608619.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase
protein_id - extdb:FAM13496-i1-1.1_001180

Gene Locus

Located on scaffold FAM13496-i1-1_scf15

FAM13496-i1-1.1_001179
FAM13496-i1-1.1_001181