update range to 10000 bp
locus tag: FAM13496-i1-1.1_001615 genome: FAM13496-i1-1.1
species: Streptococcus thermophilus taxid: 1308

Annotations

Type Name Description Pathways
KEGG reaction
 R09365 5-methyltetrahydropteroyltri-L-glutamate:L-selenohomocysteine Se-methyltransferase; Selenohomocysteine + 5-Methyltetrahydropteroyltri-L-glutamate <=> L-Selenomethionine + Tetrahydropteroyltri-L-glutamate kornec00450kornec01100
KEGG reaction
 R04405 5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase; 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine kornec00270kornec01100kornec01110kornec01230
Ortholog
 N0.HOG0004102 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
Gene Code
 metE
KEGG gene
 K00549 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14] kornec00270kornec00450kornec01100kornec01110kornec01230
Gene Ontology
 GO:1901607 alpha-amino acid biosynthetic process
Gene Ontology
 GO:1901605 alpha-amino acid metabolic process
Gene Ontology
 GO:1901576 organic substance biosynthetic process
Gene Ontology
 GO:1901566 organonitrogen compound biosynthetic process
Gene Ontology
 GO:1901564 organonitrogen compound metabolic process
Gene Ontology
 GO:0071704 organic substance metabolic process
Gene Ontology
 GO:0050667 homocysteine metabolic process
Gene Ontology
 GO:0046394 carboxylic acid biosynthetic process
Gene Ontology
 GO:0044464 obsolete cell part
Gene Ontology
 GO:0044444 obsolete cytoplasmic part
Gene Ontology
 GO:0044424 obsolete intracellular part
Gene Ontology
 GO:0044283 small molecule biosynthetic process
Gene Ontology
 GO:0044281 small molecule metabolic process
Gene Ontology
 GO:0044272 sulfur compound biosynthetic process
Gene Ontology
 GO:0044249 cellular biosynthetic process
Gene Ontology
 GO:0044238 primary metabolic process
Gene Ontology
 GO:0044237 cellular metabolic process
Gene Ontology
 GO:0043436 oxoacid metabolic process
Gene Ontology
 GO:0042085 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity
Gene Ontology
 GO:0042084 5-methyltetrahydrofolate-dependent methyltransferase activity
Gene Ontology
 GO:0032259 methylation
Gene Ontology
 GO:0019752 carboxylic acid metabolic process
Gene Ontology
 GO:0016741 transferase activity, transferring one-carbon groups
Gene Ontology
 GO:0016740 transferase activity
Gene Ontology
 GO:0016053 organic acid biosynthetic process
Gene Ontology
 GO:0009987 cellular process
Gene Ontology
 GO:0009086 methionine biosynthetic process
Gene Ontology
 GO:0009067 aspartate family amino acid biosynthetic process
Gene Ontology
 GO:0009066 aspartate family amino acid metabolic process
Gene Ontology
 GO:0009058 biosynthetic process
Gene Ontology
 GO:0008705 methionine synthase activity
Gene Ontology
 GO:0008652 cellular amino acid biosynthetic process
Gene Ontology
 GO:0008172 S-methyltransferase activity
Gene Ontology
 GO:0008168 methyltransferase activity
Gene Ontology
 GO:0008152 metabolic process
Gene Ontology
 GO:0008150 biological_process
Gene Ontology
 GO:0006807 nitrogen compound metabolic process
Gene Ontology
 GO:0006790 sulfur compound metabolic process
Gene Ontology
 GO:0006555 methionine metabolic process
Gene Ontology
 GO:0006520 cellular amino acid metabolic process
Gene Ontology
 GO:0006082 organic acid metabolic process
Gene Ontology
 GO:0005829 cytosol
Gene Ontology
 GO:0005737 cytoplasm
Gene Ontology
 GO:0005623 obsolete cell
Gene Ontology
 GO:0005622 intracellular anatomical structure
Gene Ontology
 GO:0005576 extracellular region
Gene Ontology
 GO:0005575 cellular_component
Gene Ontology
 GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Gene Ontology
 GO:0003824 catalytic activity
Gene Ontology
 GO:0003674 molecular_function
Gene Ontology
 GO:0000097 sulfur amino acid biosynthetic process
Gene Ontology
 GO:0000096 sulfur amino acid metabolic process
Eggnog Protein
 EP:metE
Eggnog Ortholog
 EO:COG0620
Eggnog Description
 ED:Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EC Number
 EC:2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase; tetrahydropteroyltriglutamate methyltransferase; homocysteine methylase; methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase; methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase; cobalamin-independent methionine synthase; methionine synthase (cobalamin-independent); MetE kornec00270kornec00450kornec01100kornec01110
Gene Product
 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase

Occurs in the following pathway maps:

Pathway Description
kornec00270 Cysteine and methionine metabolism
kornec00450 Selenocompound metabolism
kornec01100 Metabolic pathways
kornec01110 Biosynthesis of secondary metabolites
kornec01230 Biosynthesis of amino acids

Sequences

Nucleotide sequence (GC-content: 41.0 %):

ATGTCAACTACTATCATTGGTTTCCCACGTTTGGGTGAATTCCGAGAATTAAAATTTACTACAGAAAAATATTTTAGAAATGAAATTACTGCAGACGAACTTTTAGCGGCTGCTAAAGATTTGCGTGCAAAACACTGGAATATTGTTAAAGAAAAAGGTATTACTGAAATTCCTTCAAATGACTTTTCTCATTACGATAACTTCCTTGATGCGGCCTTCCTTTTCAACGTAGTTCCTGAGTCTGTGAAAAACTTGGATTTGACTGAATTGGAACAATACTTTGCTTTGGCACGTGGTTACCAAGGTGAAAAGGGGGATGTGCGTGCTCTTCCAATGAAGAAATGGTTCAACACCAACTACCATTACATCGTTCCAAAATTTGAAAAAACAACAGCAGTAAAATTGGCTGGTCACAAGATTTTTGATGAGTACCAAGAAGCCAAAGACTTGGGTCTGGATACTCGCCCAGTTGTGGTTGGACCATTCACTTTCCTTCAATTGTCTGATTTCGAAGATGGTGTGAAAGCAGAAGACTTCGTCGATAGCTTTATTGCTGCCTACCAAGATGTCTTTGCAAAATTGGCTGAACTTGGTGCTACTCGTATCCAACTTGATGAACCAGCACTTGTTAAAGATTTGACTGCTGACGAAAAAGCACTCTTCTTGAATCTGTACAATAAAATCTTGGCTGACAAGAAAGGCCTTGAGGTCTTGATTCAAACTTACTTTGGTGATGTTCGTGATGTATACAATGATCTTGTAAACTTGCCAGTAGATGCTATCGGTCTTGACTTTGTCGAAGGTAAGAAGTCGCTTGAACTTGTCAAAGGTGGATTCCCAGCTGATAAGACTCTCTATGCAGGTATTGTCAATGGTAAAAACATCTGGCGCAACAACTACGAAAAGAGTTTGGCTGTTCTTGAACAAATTCCAGCTGAAAAAATCGTATTGACAAGCTCATGCTCACTTCTTCATGTGCCATTTACGACTGCTAATGAAGAATTTGAACCAGCAATCTTGAACCACTTTGCTTTTGCCGTTGAAAAATTAGATGAACTTCGTGATTTGGATGCTATCCGTAATGGTCAAGGTGCTGAATCACTTGCTGCTAACAAAGAGCTCTTTGCTATTGAACGTGTTGGTGCAAATGCTGAACTTCGTGCTCGTATTGCAGGTTTGACAGAAGCAGATTACACACGTTTACCGGCTTTCGCAGAACGTGAAGCCATTCAAAAGGATGCCTTCAAACTTCCATTGCTTCCGACAACAACTATCGGTTCATTCCCTCAAACTAAGGAAGTTCGTGCCAAACGTTTGGCTTTCCGTAAGAATGAATTGTCTCAGGAAGAATATGATGCCTTTCTTGCTGAAATTATAGATGAATGGATTAAATGGCAAGAAGAAGTTGGCTTTGACGTCCTTGTACATGGTGAGTTTGAACGCAATGACATGGTTGAGTACTTCGGTCAAAACTTGTCTGGGTACCTCTTCTCTAAAAATGGTTGGGTGCAATCATATGGTATGCGTGGGGTGAAACCACCAATCATCTGGAGTGATGTCACTCGTCTTAATCCAATCACTGTAAAATGGTCTAGCTACGCACAAAGCCGTACTGACAAGCCTGTTAAAGGTATGTTGACTGGGCCAGTTACAATCCTCAATTGGTCATTCCCACGTGAAGATATCTCTATTAAAGATTCAACTCTTCAAATCGCTCTTGCTATCAAGGATGAAGTGCTTGACCTCGAAGCTGCAGGCATTAAGATTATCCAAATCGATGAGGCTGCTCTTCGTGAAAAATTGCCACTCCGTCGTAGTGACTGGTACGAAGACTACCTTGACTGGGCTATTCCAGCCTTCCGTTTGGTACACTCAACAGTAGCACCAGACACACAAATCCACACACACATGTGTTACTCAGAATTTACAGATATCATTCCAGCTATCGACAACTTGGATGCAGATGTTATCTCTTTTGAAGCTAGTCGTTCAAACCTTGAAATTTTGGATGAACTTAAAGCACAAAACTTCCAAACAGAAGTTGGACCTGGAGTTTATGATATCCACTCACCTCGTGTCCCACAAGACGGTGAAATTGACCACACTATCGAAGCGATCTTAGCTAAAGTTCCAAGTAGTAAAGTATGGATCAACCCTGACTGTGGTTTGAAGACTCGTGGTATTAAAGAAACTAAAGAAAGCTTAACCAAGCTTCTAGAAGCAGCAAAAGCGGCTCGCAAAAACTTGTAA

Protein sequence:

MSTTIIGFPRLGEFRELKFTTEKYFRNEITADELLAAAKDLRAKHWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPESVKNLDLTELEQYFALARGYQGEKGDVRALPMKKWFNTNYHYIVPKFEKTTAVKLAGHKIFDEYQEAKDLGLDTRPVVVGPFTFLQLSDFEDGVKAEDFVDSFIAAYQDVFAKLAELGATRIQLDEPALVKDLTADEKALFLNLYNKILADKKGLEVLIQTYFGDVRDVYNDLVNLPVDAIGLDFVEGKKSLELVKGGFPADKTLYAGIVNGKNIWRNNYEKSLAVLEQIPAEKIVLTSSCSLLHVPFTTANEEFEPAILNHFAFAVEKLDELRDLDAIRNGQGAESLAANKELFAIERVGANAELRARIAGLTEADYTRLPAFAEREAIQKDAFKLPLLPTTTIGSFPQTKEVRAKRLAFRKNELSQEEYDAFLAEIIDEWIKWQEEVGFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGMRGVKPPIIWSDVTRLNPITVKWSSYAQSRTDKPVKGMLTGPVTILNWSFPREDISIKDSTLQIALAIKDEVLDLEAAGIKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVHSTVAPDTQIHTHMCYSEFTDIIPAIDNLDADVISFEASRSNLEILDELKAQNFQTEVGPGVYDIHSPRVPQDGEIDHTIEAILAKVPSSKVWINPDCGLKTRGIKETKESLTKLLEAAKAARKNL

GenBank Info

gene - metE
locus_tag - FAM13496-i1-1.1_001615
EC_number - 2.1.1.14
inference - COORDINATES: similar to AA sequence:RefSeq:YP_003446702.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
protein_id - extdb:FAM13496-i1-1.1_001615

Gene Locus

Located on scaffold FAM13496-i1-1_scf25

Cellular location expand

Responsible annotations:
SL-0243: GO:0005576 extracellular region
SL-0229: GO:0005622 intracellular anatomical structure
SL-0086: GO:0005737 cytoplasm
SL-0091: GO:0005829 cytosol
FAM13496-i1-1.1_001614
FAM13496-i1-1.1_001616