update range to 10000 bp
locus tag: FAM19038-p1-1.1_001765 genome: FAM19038-p1-1.1
species: Acidipropionibacterium jensenii taxid: 1749

Annotations

Type Name Description Pathways
KEGG reaction
 R11765 tetrahydrobiopterin:NADP+ oxidoreductase (7,8-dihydrobiopterin-forming); Tetrahydrobiopterin + NADP+ <=> 7,8-Dihydrobiopterin + NADPH + H+ kornec00790kornec01100kornec01240
KEGG reaction
 R02236 dihydrofolate:NADP+ oxidoreductase; Dihydrofolate + NADP+ <=> Folate + NADPH + H+ kornec00670kornec00790kornec01100kornec01240
KEGG reaction
 R02235 dihydrofolate:NAD+ oxidoreductase; Dihydrofolate + NAD+ <=> Folate + NADH + H+ kornec00670kornec00790kornec01100kornec01240
KEGG reaction
 R00940 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase; Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+ kornec00670kornec00790kornec01100kornec01240
KEGG reaction
 R00939 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase; Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+ kornec00670kornec00790kornec01100kornec01240
KEGG reaction
 R00937 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase; Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+ kornec00670kornec00790kornec01100kornec01240
KEGG reaction
 R00936 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase; Tetrahydrofolate + NAD+ <=> Dihydrofolate + NADH + H+ kornec00670kornec00790kornec01100kornec01240
Ortholog
 N0.HOG0001400 dihydrofolate reductase
KEGG gene
 K00287 DHFR, folA; dihydrofolate reductase [EC:1.5.1.3] kornec00670kornec00790kornec01100kornec01240kornec01523
Eggnog Protein
 EP:folA
Eggnog Ortholog
 EO:COG0262
Eggnog Description
 ED:Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis
EC Number
 EC:1.5.1.3 dihydrofolate reductase; tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase kornec00670kornec00790kornec01100
Gene Product
 dihydrofolate reductase

Occurs in the following pathway maps:

Pathway Description
kornec00670 One carbon pool by folate
kornec00790 Folate biosynthesis
kornec01100 Metabolic pathways
kornec01240 Biosynthesis of cofactors
kornec01523 Antifolate resistance

Sequences

Nucleotide sequence (GC-content: 71.0 %):

ATGCAGGTGATCGCCATCGCCGCGGTGGCCGACGACGGGTCGATCGGCTCGGGGGAGGACATGCTGTGGCACATCCCCGAGGACTTCCGACGGTTCAAGAGGGTGACGATGGGCCACACCCTGGTCTTCGGCCGACGGACCTTCGAGCAGATCGGCAGGCTTCCCGGGCGCCGGCACATCGTGTGCACCCGGGACCGGTCCTGGTCGGCGCAGGGGGTCGACGTCGCCCACTCGGTGCCCCGGGCCGTGGAGATGGCCCGACAGGCCGGTGAACAGATCTGCTACATCGCCGGTGGGGCGCAGATCTACGCCGACGCCCTCGGCCTGTGCACCGGCCTGGACATCACCGAGGTGCACCGCCGACCCGGCGGTGCGGCGCGGTTCCCGCAGATCACCCCCGACAGCTGGCGGGAGGTCTCCCGCCAGCGGCACGAGGGATTCGACTTCGTGCAGTACCTGCCGGTCCGGGCCGCCGGCGAGGACTGA

Protein sequence:

MQVIAIAAVADDGSIGSGEDMLWHIPEDFRRFKRVTMGHTLVFGRRTFEQIGRLPGRRHIVCTRDRSWSAQGVDVAHSVPRAVEMARQAGEQICYIAGGAQIYADALGLCTGLDITEVHRRPGGAARFPQITPDSWREVSRQRHEGFDFVQYLPVRAAGED

GenBank Info

locus_tag - FAM19038-p1-1.1_001765
inference - COORDINATES: similar to AA sequence:RefSeq:WP_016665918.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - dihydrofolate reductase
protein_id - extdb:FAM19038-p1-1.1_001765

Gene Locus

Located on scaffold FAM19038-p1-1_scf1

FAM19038-p1-1.1_001764
FAM19038-p1-1.1_001766