update range to 10000 bp
locus tag: FAM19038-p1-1.1_002552 genome: FAM19038-p1-1.1
species: Acidipropionibacterium jensenii taxid: 1749

Annotations

Type Name Description Pathways
KEGG reaction
 R01213 acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating); alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O kornec00290kornec00620kornec01100kornec01110kornec01210kornec01230
Ortholog
 N0.HOG0002629 2-isopropylmalate synthase
Gene Code
 leuA
KEGG gene
 K01649 leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13] kornec00290kornec00620kornec01100kornec01110kornec01210kornec01230
Eggnog Protein
 EP:leuA
Eggnog Ortholog
 EO:COG0119
Eggnog Description
 ED:Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EC Number
 EC:2.3.3.13 2-isopropylmalate synthase; 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating); alpha-isopropylmalate synthetase; alpha-isopropylmalate synthase; alpha-isopropylmalic synthetase; isopropylmalate synthase; isopropylmalate synthetase kornec00290kornec00620kornec01100kornec01110
Gene Product
 2-isopropylmalate synthase

Occurs in the following pathway maps:

Pathway Description
kornec00290 Valine, leucine and isoleucine biosynthesis
kornec00620 Pyruvate metabolism
kornec01100 Metabolic pathways
kornec01110 Biosynthesis of secondary metabolites
kornec01210 2-Oxocarboxylic acid metabolism
kornec01230 Biosynthesis of amino acids

Sequences

Nucleotide sequence (GC-content: 67.3 %):

ATGACCCGCCCACAGTCCTCACCCTGCCAGTTGACCTCACCGATGCCGGTCGACCGCTACAAGCCCTTCATCCCGCAGTCGCTGCCCGATCGCACCTGGCCCGACAAGACCCTCGACAAGGCACCCCGATGGCTGTCGACCGATCTGCGCGACGGCAACCAGGCCCTGATCGACCCGATGACCGTCTCGCGCAAGGTGCGGATGTTCAACCTGCTCATCGAGATGGGCTACAAGGAGATCGAGATCGGCTTCCCCTCGGCCTCCCAGACCGAGTACGACTTCGTGCGCAAGCTGATCGAGGAGGACGTCGTTCCCGACGACGTCACGATCTCGGTGCTGACCCAGGCCCGCGAGGACCTCATCCGCCGCACCGCGCAGAGCCTGGTCGGCGCCCACCGCGCCACCATCCACATGTACAACGCGACCGCCGAGCTGTTCCGCCGGGTGGTCTTCCACGTCAACGAGCAGCAGTGCATCGACCTGGCCCACCAGGGCACCGAATGGGTCGTCAAGTACGCCGAGGAGTACCTGGACGACGTCGAGTTCGGTTACGAGTACTCCCCGGAGATCTTCACCCAGACCCCGACCGACTTCGCCCTGGAGGTGTGCGAGTCGGTGATGGACGTCTGGCAGCCCGCCGAGGGCCGCGAGATCATCCTCAACCTGCCCGCCACCGTGGAGATGAGCACCCCGAACACCTTCGGCGACCAGATCGAGTACTTCTGCCGCAACATCCGCGACCGCCAGCACGTGTGCGTCTCGGTGCACCCCCACAACGACCGGGGTACCGGCGTCGCGGCCGCCGAGTTCGCCCAGATGGCCGGCGCCGACCGGGTCGAGGGATGCCTCTTCGGCCACGGCGAGAGAACCGGCAATGTCGACCTGGTCACCCTGGGGATGAACCTGTTCAGCCAGGGCGTCGACCCGAAGATCGACTTCTCCGACATGCCCCAGATCCGCCGCACCGTCGAGTACTGCACCGGGCTGCCGGTGCCGGCCCGCCAGCCCTACTCCGGCGACCTGGTCTTCACCGCCTTCTCCGGCTCCCACCAGGACGCCATCAAGAAGGGCCTGGAGGACCTGCAGCGGATCGCCGACGAGCAGGGCGTCGATGAGCGCAAGGTGACCTGGCAGGCCCCCTACCTGGCCGTCGACCCGCACGACATCGGCCGCACCTACGAGGCCGTCATCCGCGTCAACAGCCAGTCCGGCAAGGGCGGGATGGCCTACCTGATGAAGACCGAGCACCAGGTGGACCTGCCCCGGCGTCTGCAGATCGAGTTCTCCAAGTCGGTGCAGTTCCTCACCGACCAGGAGGCCCGCGAGATCAGCCACGACGAGATCTGGGACCTGTTCTCCCGGGAGTACCTTCACACCGACGGGATCCAGCTGGTCTCCCGCGAGTCCGCCACCCGCGGGGGCAGTCACGAGATCACCGCGACGATCGGGGTCGACGGCGCCCAGCGCACCATCTCCGGTGAAGGCAACGGCGCGGTCTCGGCCTTCGTCGACGCCCTGGACTCGCTCGGCGTGGTCGTCCACGTGCTGGACTACTCCGAGCACGCGATGACCGCAGGCGGCACCGCGAAGGCCGCCGCCTATGTGGAGTGCGAGGTCGGCGACGGGGAGTCCAGCCAGATCCTGTGGGGTGTCGGCATCGACTCCGACATCACCGAGGCCTCTCTCAAGGCGGTCATCGGGGCCGTCAACCGGTCCGGCGCGAGGGTGCAGGTCGACGAACGGGTCGGTTCCCGACAGGGCTGA

Protein sequence:

MTRPQSSPCQLTSPMPVDRYKPFIPQSLPDRTWPDKTLDKAPRWLSTDLRDGNQALIDPMTVSRKVRMFNLLIEMGYKEIEIGFPSASQTEYDFVRKLIEEDVVPDDVTISVLTQAREDLIRRTAQSLVGAHRATIHMYNATAELFRRVVFHVNEQQCIDLAHQGTEWVVKYAEEYLDDVEFGYEYSPEIFTQTPTDFALEVCESVMDVWQPAEGREIILNLPATVEMSTPNTFGDQIEYFCRNIRDRQHVCVSVHPHNDRGTGVAAAEFAQMAGADRVEGCLFGHGERTGNVDLVTLGMNLFSQGVDPKIDFSDMPQIRRTVEYCTGLPVPARQPYSGDLVFTAFSGSHQDAIKKGLEDLQRIADEQGVDERKVTWQAPYLAVDPHDIGRTYEAVIRVNSQSGKGGMAYLMKTEHQVDLPRRLQIEFSKSVQFLTDQEAREISHDEIWDLFSREYLHTDGIQLVSRESATRGGSHEITATIGVDGAQRTISGEGNGAVSAFVDALDSLGVVVHVLDYSEHAMTAGGTAKAAAYVECEVGDGESSQILWGVGIDSDITEASLKAVIGAVNRSGARVQVDERVGSRQG

GenBank Info

gene - leuA
locus_tag - FAM19038-p1-1.1_002552
EC_number - 2.3.3.13
inference - COORDINATES: similar to AA sequence:RefSeq:WP_016667432.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - 2-isopropylmalate synthase
protein_id - extdb:FAM19038-p1-1.1_002552

Gene Locus

Located on scaffold FAM19038-p1-1_scf1

FAM19038-p1-1.1_002551
FAM19038-p1-1.1_002553