update range to 10000 bp
locus tag: FAM19038-p1-1.1_002667 genome: FAM19038-p1-1.1
species: Acidipropionibacterium jensenii taxid: 1749

Annotations

Type Name Description Pathways
KEGG reaction
 R04241 tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming); ATP + THF-polyglutamate(n) + L-Glutamate <=> ADP + Orthophosphate + THF-polyglutamate(n+1) kornec00790kornec01240
KEGG reaction
 R02237 7,8-dihydropteroate:L-glutamate ligase (ADP-forming); ATP + Dihydropteroate + L-Glutamate <=> ADP + Orthophosphate + Dihydrofolate kornec00790kornec01100kornec01240
KEGG reaction
 R00942 Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming); ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + THF-L-glutamate kornec00790kornec01240
Ortholog
 N0.HOG0000877 bifunctional folylpolyglutamate synthase/dihydrofolate synthase
KEGG gene
 K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] kornec00790kornec01100kornec01240
Gene Ontology
 GO:1901576 organic substance biosynthetic process
Gene Ontology
 GO:1901566 organonitrogen compound biosynthetic process
Gene Ontology
 GO:1901564 organonitrogen compound metabolic process
Gene Ontology
 GO:1901362 organic cyclic compound biosynthetic process
Gene Ontology
 GO:1901360 organic cyclic compound metabolic process
Gene Ontology
 GO:0071704 organic substance metabolic process
Gene Ontology
 GO:0051188 obsolete cofactor biosynthetic process
Gene Ontology
 GO:0051186 obsolete cofactor metabolic process
Gene Ontology
 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process
Gene Ontology
 GO:0046900 tetrahydrofolylpolyglutamate metabolic process
Gene Ontology
 GO:0046483 heterocycle metabolic process
Gene Ontology
 GO:0046452 dihydrofolate metabolic process
Gene Ontology
 GO:0046394 carboxylic acid biosynthetic process
Gene Ontology
 GO:0044464 obsolete cell part
Gene Ontology
 GO:0044424 obsolete intracellular part
Gene Ontology
 GO:0044283 small molecule biosynthetic process
Gene Ontology
 GO:0044281 small molecule metabolic process
Gene Ontology
 GO:0044271 cellular nitrogen compound biosynthetic process
Gene Ontology
 GO:0044249 cellular biosynthetic process
Gene Ontology
 GO:0044237 cellular metabolic process
Gene Ontology
 GO:0043650 dicarboxylic acid biosynthetic process
Gene Ontology
 GO:0043648 dicarboxylic acid metabolic process
Gene Ontology
 GO:0043604 amide biosynthetic process
Gene Ontology
 GO:0043603 cellular amide metabolic process
Gene Ontology
 GO:0043436 oxoacid metabolic process
Gene Ontology
 GO:0042559 pteridine-containing compound biosynthetic process
Gene Ontology
 GO:0042558 pteridine-containing compound metabolic process
Gene Ontology
 GO:0042398 cellular modified amino acid biosynthetic process
Gene Ontology
 GO:0034641 cellular nitrogen compound metabolic process
Gene Ontology
 GO:0019752 carboxylic acid metabolic process
Gene Ontology
 GO:0019438 aromatic compound biosynthetic process
Gene Ontology
 GO:0018130 heterocycle biosynthetic process
Gene Ontology
 GO:0016881 acid-amino acid ligase activity
Gene Ontology
 GO:0016879 ligase activity, forming carbon-nitrogen bonds
Gene Ontology
 GO:0016874 ligase activity
Gene Ontology
 GO:0016053 organic acid biosynthetic process
Gene Ontology
 GO:0009987 cellular process
Gene Ontology
 GO:0009396 folic acid-containing compound biosynthetic process
Gene Ontology
 GO:0009108 obsolete coenzyme biosynthetic process
Gene Ontology
 GO:0009058 biosynthetic process
Gene Ontology
 GO:0008841 dihydrofolate synthase activity
Gene Ontology
 GO:0008152 metabolic process
Gene Ontology
 GO:0008150 biological_process
Gene Ontology
 GO:0006807 nitrogen compound metabolic process
Gene Ontology
 GO:0006761 dihydrofolate biosynthetic process
Gene Ontology
 GO:0006760 folic acid-containing compound metabolic process
Gene Ontology
 GO:0006732 obsolete coenzyme metabolic process
Gene Ontology
 GO:0006725 cellular aromatic compound metabolic process
Gene Ontology
 GO:0006575 cellular modified amino acid metabolic process
Gene Ontology
 GO:0006082 organic acid metabolic process
Gene Ontology
 GO:0005737 cytoplasm
Gene Ontology
 GO:0005623 obsolete cell
Gene Ontology
 GO:0005622 intracellular anatomical structure
Gene Ontology
 GO:0005575 cellular_component
Gene Ontology
 GO:0004326 tetrahydrofolylpolyglutamate synthase activity
Gene Ontology
 GO:0003824 catalytic activity
Gene Ontology
 GO:0003674 molecular_function
Eggnog Protein
 EP:folC
Eggnog Ortholog
 EO:COG0285
Eggnog Description
 ED:Mur ligase middle domain
EC Number
 EC:6.3.2.17 tetrahydrofolate synthase; folylpolyglutamate synthase; folate polyglutamate synthetase; formyltetrahydropteroyldiglutamate synthetase; N10-formyltetrahydropteroyldiglutamate synthetase; folylpoly-gamma-glutamate synthase; folylpolyglutamyl synthetase; folylpoly(gamma-glutamate) synthase; folylpolyglutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming); tetrahydropteroyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) kornec00790kornec01100
EC Number
 EC:6.3.2.12 dihydrofolate synthase; dihydrofolate synthetase; 7,8-dihydrofolate synthetase; H2-folate synthetase; 7,8-dihydropteroate:L-glutamate ligase (ADP); dihydropteroate:L-glutamate ligase (ADP-forming); DHFS kornec00790kornec01100
Gene Product
 bifunctional folylpolyglutamate synthase/dihydrofolate synthase

Occurs in the following pathway maps:

Pathway Description
kornec00790 Folate biosynthesis
kornec01100 Metabolic pathways
kornec01240 Biosynthesis of cofactors

Sequences

Nucleotide sequence (GC-content: 70.9 %):

CTGCAGGCACGCTGGCCCGAGCACCGGATCGGCCCGGGGCTGGATCGCGAGAGGGCGATCCTGGACCTGCTCGGCAACCCCGAGCGGGCCTACCCGGTGATCCAGGTCGCGGGGACCAATGGCAAGGGGTCCACCGCGATCATGATCGACTCCCTGCTGCGGGCCGCCGGTCTGTGGGTGGGTCGGTACACCTCACCGCACCTGGTGGACCTGCGGGAGCGGATCTGCATCGACGGCGAGCCGGTCGGCGTCGAACGGTTCGATGAGATCTGGGAGCAGATCGCACCGATGGTGCGAATGGTCGACGAGCAGCACATCGACGGCATCGAGCCGACCTTCTTCGAGGTGATGACGGCGATGGCCTTCGCGACCTTCGCCGACACCCCGGTCGACGTCGCGGTGGTCGAGGTGGGCCTGGGGGGCCGGTGGGACGCCACCAACGTGGTCGACGCCCAGGTCGCCGTGGTCGCCCCGGTGGCGATGGACCACATGCACATCCTCGGTGACACGCTGGCCAAGATCGCCGGCGAGAAGGCGGGGATCATCAAGCCGGTGAGCAGCGCGGTGATCGCCGGCCAGAAGCCGGAGGCCGCCCAGGTGCTGCTGGCCCAGTGCGCCGACGTGGGGGTCAAGCCGATCCTCGAGGGGCCGGACTTCGGGCTGCTGGACCGCCGTGGCGCGGTCGGCGGCCAGGTGATCCGGATCCAGACCGCCGGCGGCCCGCTGGGGGAGCTCTTCCTGCCGCTGTTCGGCGAGCACATGGCGCACAACGCCGCCCTGGCGGTGGCCGCCGTGGAGACCTTCATGGGAGGCAAGCCGCTCAACCCCGAGATCATCGAGCAGGGACTGGCCGATGTGGTCGCCCCGGCCCGGCTCGAGGTGGTGCGGCGGACCCCCACCATCGTGCTGGACACCTTCCACAACCCGCACGGTGCGCACTCGGCGATGGCCGGGGTCACCGAGGCCTTCGACCTGAACCCGCTGGTCGCCGTCGTCGCCGCGATGCGCGACAAGGACGTCGACGGGGTGCTCTCGGAGATGTCGGAGGCGGTCGGCCGGGTGGTCCTCACCACCATGCCGGAGCTGCCCCGGGCACTGCCGGTGGCCGAACTCGACGAGATCGCCTCGAAGTACTGGGACGCCGACCACCGGATGACCTGTCCGACGGTCTCCCAGGCCCTCGAGGAGGCGGTCCGGATCGCCGACATGTCCGGCCCCGGTGCCGGCGTGCTCGTCGGCGGGTCGGCGGTGCTGGCCGGCCAGGCCAGAGCCATCCTGGTGCCCGACGGGATCAATCACGTCCATGCCGGGCCGCAGGCGGTGGTGGAGACCCCTCAGCTGTCCGAGGAGCAGATCGCCGCCATGGAGGGGGAGGTTCTCGAGCCCGTCGAGGAGGATCCCACCGACGGCGACGAGGAGTCCTGGTGA

Protein sequence:

MQARWPEHRIGPGLDRERAILDLLGNPERAYPVIQVAGTNGKGSTAIMIDSLLRAAGLWVGRYTSPHLVDLRERICIDGEPVGVERFDEIWEQIAPMVRMVDEQHIDGIEPTFFEVMTAMAFATFADTPVDVAVVEVGLGGRWDATNVVDAQVAVVAPVAMDHMHILGDTLAKIAGEKAGIIKPVSSAVIAGQKPEAAQVLLAQCADVGVKPILEGPDFGLLDRRGAVGGQVIRIQTAGGPLGELFLPLFGEHMAHNAALAVAAVETFMGGKPLNPEIIEQGLADVVAPARLEVVRRTPTIVLDTFHNPHGAHSAMAGVTEAFDLNPLVAVVAAMRDKDVDGVLSEMSEAVGRVVLTTMPELPRALPVAELDEIASKYWDADHRMTCPTVSQALEEAVRIADMSGPGAGVLVGGSAVLAGQARAILVPDGINHVHAGPQAVVETPQLSEEQIAAMEGEVLEPVEEDPTDGDEESW

GenBank Info

locus_tag - FAM19038-p1-1.1_002667
inference - COORDINATES: similar to AA sequence:RefSeq:WP_002531002.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - bifunctional folylpolyglutamate synthase/dihydrofolate synthase
protein_id - extdb:FAM19038-p1-1.1_002667

Gene Locus

Located on scaffold FAM19038-p1-1_scf1

Cellular location expand

Responsible annotations:
SL-0229: GO:0005622 intracellular anatomical structure
SL-0086: GO:0005737 cytoplasm
FAM19038-p1-1.1_002666
FAM19038-p1-1.1_002668