update range to 10000 bp
locus tag: FAM19471-i1-1.1_000413 genome: FAM19471-i1-1.1
species: Limosilactobacillus fermentum taxid: 1613

Annotations

Type Name Description Pathways
KEGG reaction
 R04241 tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming); ATP + THF-polyglutamate(n) + L-Glutamate <=> ADP + Orthophosphate + THF-polyglutamate(n+1) kornec00790kornec01240
KEGG reaction
 R02237 7,8-dihydropteroate:L-glutamate ligase (ADP-forming); ATP + Dihydropteroate + L-Glutamate <=> ADP + Orthophosphate + Dihydrofolate kornec00790kornec01100kornec01240
KEGG reaction
 R00942 Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming); ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + THF-L-glutamate kornec00790kornec01240
Ortholog
 N0.HOG0000877 bifunctional folylpolyglutamate synthase/dihydrofolate synthase
KEGG gene
 K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] kornec00790kornec01100kornec01240
Eggnog Protein
 EP:folC
Eggnog Ortholog
 EO:COG0285
Eggnog Description
 ED:Belongs to the folylpolyglutamate synthase family
EC Number
 EC:6.3.2.17 tetrahydrofolate synthase; folylpolyglutamate synthase; folate polyglutamate synthetase; formyltetrahydropteroyldiglutamate synthetase; N10-formyltetrahydropteroyldiglutamate synthetase; folylpoly-gamma-glutamate synthase; folylpolyglutamyl synthetase; folylpoly(gamma-glutamate) synthase; folylpolyglutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming); tetrahydropteroyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) kornec00790kornec01100
EC Number
 EC:6.3.2.12 dihydrofolate synthase; dihydrofolate synthetase; 7,8-dihydrofolate synthetase; H2-folate synthetase; 7,8-dihydropteroate:L-glutamate ligase (ADP); dihydropteroate:L-glutamate ligase (ADP-forming); DHFS kornec00790kornec01100
Gene Product
 bifunctional folylpolyglutamate synthase/dihydrofolate synthase

Occurs in the following pathway maps:

Pathway Description
kornec00790 Folate biosynthesis
kornec01100 Metabolic pathways
kornec01240 Biosynthesis of cofactors

Sequences

Nucleotide sequence (GC-content: 58.1 %):

ATGGAAGAGATTACAACTTACGACCAGGCCCTAGCCTTCATTCACGGCCGGACCCGGTTCAAAAAAATTCCGACCCTCAAAAGAATGCGCCTCTTTTTGGAGCGGCTCGGCAACCCCCAAGAGGGCCTGAACATGATCCACATCACCGGGACCAACGGTAAGGGGTCGACGGTGGCGATGACTAGGGACATCTTGGGCGCCAGTGGCCTGCGCGTGGGGACCTTCACGTCGCCCTTCATTACCCGCTACAACGAACGGATGGCCATCGATGGGCAGCCAATTAGTGACGAAGATTTGACCCGGATCGCTAACCGGGTCGCCAAGGTGGCGACGGTGTTAGACCAGGAGCTAACGGAGGGCGGGCCGACCGAGTTTGAAATCGGTACGGCGATTATGTTTTGCTATATGAATGAGCAACGCCCCGACCTGGTCATTTTAGAGGTGGGGATTGGGGGCAAGTGGGATTCAACCAACGTGATCGAAGCCCCCTTGGTAACGGCGATTACGACCGTCGGTTACGACCACATGCGCTACCTGGGCGACACCTATGAACAGATCGCTAGCCACAAGGCGGGAATCATCAAGGAGGGGGCGCCGCTAGTCATTGGTCACCTCCCGACCAGTGCCCGGGAAGTGGTGGCCCAAGTGGCCAAAGCTCACCACGCTAAATTGTATGAGCTCGGGACCGACTTTGACGCACCAAACGTCACTCCCCACGCCCTGTACCCAACCGTTTCATACTCGGGGCTAGGGCTACACCGGGCCCAGTTTAAGTTGGGCCTGGCCGGCGACTACCAGGTGGCAAACGCCGCCGTGGCGATCACGGTTAGCCAACTGGCCTTAGCCGCCCTGGGGCTACCGGTGCTAGCCAAGGACGTCAGGCGGGGCTTAGAAGAAAGTGCCTGGCCGGCCCGGATGGAAGTAGTTAACGATGAACCACTGATGATTTTAGACGGGGCCCATAACCTGCCGGGGGTGCAGGCGCTCGTGCAAACGATCAAGGACGACTTTTTTGATCGGCAGGTCTACTTGGAAGTGGCGATCCTGGCCGATAAGCAGTATGAACTGATGCTGGGCGAATTAGCGAGCCTGGCCAACGTTCACTTGCTGGTGACTCACTTTGCCGGGCCGGCAGCGAGCCGCCCCAGTGCGGACCTAGGATTGGCCGTTAAGGAACTGGCGACCCGCTACCCGGTGGAATACGTCCCTAACTGGCAGTTGGGGATCGCCCGGCTGGCCCAAGAGGCCCAGGGTGACGACGTAATCATCATCACCGGCTCCTTGTACTTTGTTTCCGAAGTTCGCCAATTTTTATTAGACTAA

Protein sequence:

MEEITTYDQALAFIHGRTRFKKIPTLKRMRLFLERLGNPQEGLNMIHITGTNGKGSTVAMTRDILGASGLRVGTFTSPFITRYNERMAIDGQPISDEDLTRIANRVAKVATVLDQELTEGGPTEFEIGTAIMFCYMNEQRPDLVILEVGIGGKWDSTNVIEAPLVTAITTVGYDHMRYLGDTYEQIASHKAGIIKEGAPLVIGHLPTSAREVVAQVAKAHHAKLYELGTDFDAPNVTPHALYPTVSYSGLGLHRAQFKLGLAGDYQVANAAVAITVSQLALAALGLPVLAKDVRRGLEESAWPARMEVVNDEPLMILDGAHNLPGVQALVQTIKDDFFDRQVYLEVAILADKQYELMLGELASLANVHLLVTHFAGPAASRPSADLGLAVKELATRYPVEYVPNWQLGIARLAQEAQGDDVIIITGSLYFVSEVRQFLLD

GenBank Info

locus_tag - FAM19471-i1-1.1_000413
inference - COORDINATES: similar to AA sequence:RefSeq:WP_003685998.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - bifunctional folylpolyglutamate synthase/dihydrofolate synthase
protein_id - extdb:FAM19471-i1-1.1_000413

Gene Locus

Located on scaffold FAM19471-i1-1_scf5

FAM19471-i1-1.1_000412
FAM19471-i1-1.1_000414