update range to 10000 bp
locus tag: FAM19471-i1-1.1_000886 genome: FAM19471-i1-1.1
species: Limosilactobacillus fermentum taxid: 1613

Annotations

Type Name Description Pathways
KEGG reaction
 R03270 2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate kornec00010kornec00020kornec00620
KEGG reaction
 R01699 pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating); Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
KEGG reaction
 R00209 pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex; Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+ kornec01100kornec01110kornec01120kornec01200
KEGG reaction
 R00014 pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating); Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 kornec00010kornec00020kornec00620
Gene Product
 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha
Gene Code
 pdhA
Ortholog
 N0.HOG0001109 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha
KEGG gene
 K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1] kornec00010kornec00020kornec00620kornec01100kornec01110kornec01120kornec01200kornec04066kornec04922kornec05230
Eggnog Protein
 EP:pdhA
Eggnog Ortholog
 EO:COG1071
Eggnog Description
 ED:Dehydrogenase E1 component
EC Number
 EC:1.2.4.1 pyruvate dehydrogenase (acetyl-transferring); pyruvate decarboxylase (ambiguous); pyruvate dehydrogenase (ambiguous); pyruvate dehydrogenase (lipoamide); pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating); pyruvic acid dehydrogenase; pyruvic dehydrogenase (ambiguous) kornec00010kornec00020kornec00620kornec01100kornec01110kornec01120

Occurs in the following pathway maps:

Pathway Description
kornec00010 Glycolysis / Gluconeogenesis
kornec00020 Citrate cycle (TCA cycle)
kornec00620 Pyruvate metabolism
kornec01100 Metabolic pathways
kornec01110 Biosynthesis of secondary metabolites
kornec01120 Microbial metabolism in diverse environments
kornec01200 Carbon metabolism
kornec04066 HIF-1 signaling pathway
kornec04922 Glucagon signaling pathway
kornec05230 Central carbon metabolism in cancer

Sequences

Nucleotide sequence (GC-content: 50.5 %):

ATGAAAAAGTTAGACTTTGAAAGCCTTAAGCACAACCCTGAGTACGAGGTTCTTCAGGTCCTCGGTACTGATGGCAAGGTTGTCAATGAGGACTTAATGCCAGACCTAACCGATGATCAATTGGTAGATCTGTTTAAGCAAATGATTTGGTCCCGATTAGTTGGTGACCAAACTGCTAAGCTTAGCCGTCAAGGCCGGTTAGGTTTCTTCGCCCCAACTGCCGGGGAAGAAGCCAGCCAAATGGGTTCCAACTTCGCGATGACCAAGGACGACTTCCTCTTGGGTGCATATCGTGACGTCCCACAATTGATCAAGCACGGTCTGTCCTTAGCTAAGGGCTTCATGTGGTCTAAGGGTCACTACAACGCTAACGACTACCCAGAAGAATTGAACGCTTTGCCACCACAAATCATCATTGGTGCTCAATACGCTCAAACTGCTGGGGTTGCCCTTGGGATCAAGCTCAACGGCGACAAGAAGGTTGCCTACACCTACACTGGTGACGGTGGTACTTCGCAGGGTGACTTCTACGAAGGGATTAACTTCGCAGGGGCTTACCAAGCACCGGCTGTCTTCTTTGTTCAAAACAACGGTTACGCTATCTCCGTTCCACGGAAGCTGCAAACCGCTGCTCCAACCCTGGCTCAAAAGGGTGTGGCTGCCGGAATTCCTTCCATCGTAGTTGACGGGATGGACGCCCTGGCGGTTTATGCTGCTGCTAAGCAAGCACGTGACTACGCCGTTGAAGGTAATGGTCCAGTGATCATCGAAACGCTGACTTACCGTTACGGACCACACACCCTTTCTGGTGACGACCCAACCCGTTACCGGACTAAGGAAGAAGAAGACGAATGGCACGCAAAGGACCCACTGGTTCGGATGCGTAAGTTCCTGACTGACAAGGGTCTTTGGGACGACGCCAGGGAAGAAGCCTACAACGCTGAAGTGGCTAAGGAAATCGACGACGCTATCAAGGAAGTTGAAAGCCAACCAGCTCAAAAGGCATCTGACTTCTTGAAGTTCGAATTTGTCGACACTCCAGGTGCTATTCAACGTGAAATCGATGAGTACGAAGAAAAGGAGGCCAAATAA

Protein sequence:

MKKLDFESLKHNPEYEVLQVLGTDGKVVNEDLMPDLTDDQLVDLFKQMIWSRLVGDQTAKLSRQGRLGFFAPTAGEEASQMGSNFAMTKDDFLLGAYRDVPQLIKHGLSLAKGFMWSKGHYNANDYPEELNALPPQIIIGAQYAQTAGVALGIKLNGDKKVAYTYTGDGGTSQGDFYEGINFAGAYQAPAVFFVQNNGYAISVPRKLQTAAPTLAQKGVAAGIPSIVVDGMDALAVYAAAKQARDYAVEGNGPVIIETLTYRYGPHTLSGDDPTRYRTKEEEDEWHAKDPLVRMRKFLTDKGLWDDAREEAYNAEVAKEIDDAIKEVESQPAQKASDFLKFEFVDTPGAIQREIDEYEEKEAK

GenBank Info

gene - pdhA
locus_tag - FAM19471-i1-1.1_000886
inference - COORDINATES: similar to AA sequence:RefSeq:WP_014562492.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha
protein_id - extdb:FAM19471-i1-1.1_000886

Gene Locus

Located on scaffold FAM19471-i1-1_scf13

FAM19471-i1-1.1_000885
FAM19471-i1-1.1_000887