update range to 10000 bp
locus tag: FAM13496-i1-1.1_001328 genome: FAM13496-i1-1.1
species: Streptococcus thermophilus taxid: 1308

Annotations

Type Name Description Pathways
Gene Product
 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase
KEGG reaction
 R02788 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming); UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate ligase (ADP-forming); ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-Diaminoheptanedioate <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate kornec00300kornec00550kornec01100
KEGG reaction
 R02786 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming); UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase (ADP-forming); ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-Lysine <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine kornec00550kornec01100
Ortholog
 N0.HOG0001106 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
KEGG gene
 K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] kornec00550kornec01100
KEGG gene
 K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13] kornec00300kornec00550kornec01100
Eggnog Protein
 EP:murE
Eggnog Ortholog
 EO:COG0769
Eggnog Description
 ED:to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EC Number
 EC:6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase; MurE synthetase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase; uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase; UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming) kornec00550kornec01100
EC Number
 EC:6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase; MurE synthetase [ambiguous]; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming); UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase; UDP-N-acetylmuramoylalanyl-D-glutamate---2,6-diaminopimelate ligase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming) kornec00300kornec00550kornec01100

Occurs in the following pathway maps:

Pathway Description
kornec00300 Lysine biosynthesis
kornec00550 Peptidoglycan biosynthesis
kornec01100 Metabolic pathways

Sequences

Nucleotide sequence (GC-content: 42.3 %):

ATGATTACTATTGAACAAGTTCTAGAGGTTCTCAAAAAGGACCATAATTTTAGAGATATTATCAACCAAGAGTACTACTACTATTCATGGACTGGGGTGACTTTTGATCATCTTTCTTACGACAGTCGTGATATCACACCATCTACCCTATTTTTTGCCAAGGGAGCTGGCTTCAAACTTGAGTTTTTGGAGAGTGCTGTCCAGGCTGGATTAGGCTTCTACGTGGCTGAAAAAGATTACCAAGTAGGTATCCCTGCAATTCTCGTTTCAGATATCAAGCAAGCTATGAGTCTCGTTGCTCAGGCCTTCTACCAACACCCTCAAGACAAACTAAAACTACTAGCCTTTACTGGTACAAAAGGGAAGACAACAGCGTCTTACTTTGCCTTTAACATACTTAAGCAAAGTCATAAGCCTGCCATGCTCTCAACCATGAACACGACACTGGACGGAAAAACCTTCTTCAAATCTAACTTAACTACACCTGAAAGTTTGGACCTTTTCCGTATGATGGCTGAAGCTGTATCTAACGGCATGACCCACCTGATTATGGAAGTTTCAAGTCAGGCCTATCTAACCAAGCGTGTCTATGGTTTGACCTTTGATGTAGGTGTCTTTCTTAACATCAGTCCAGACCACATTGGACCTATTGAACACCCAACCTTTGAAGACTACTTCTACCACAAGCGTCTCCTCTTGAAAAATAGTCAAGCAGTTATTGTCAATAGTGGTATGAATCACTTCGATTTTGTTGCTGAAGAAGTCGCTGATAAAGACCACGACTTCTATGGTAAGGACTCTGAAAATACCGTTAAACATAGCTCAGGTTTTAGCTTTAAAGCCAAAGGTAAACTAGCTGGTGATTACGATATCCAACTCATTGGTGACTTTAATCAGGATAACGCCATGGCTGCTGGTTTAGCCTGCCTACGTCTTGGAGCCAGTCTTGAAGATATTAAAAAAGGGATTGCTCAAACCTCTGTTCCAGGCCGTATGGAAATTCTCACTCAGGCAAATGGTGCTAAGGTATTCGTCGACTATGCTCACAATGGTGACAGCCTAGACAAGCTCTTGCAAGTCGTAACTGACCACCAAAAAGGTAAGATTAGTTTGATTCTAGGAGCTCCTGGGAATAAGGGCGAGAGCCGTCGTCAAGACTTTGGTCACGTCCTCAACACTTACCCCGAAATAAATGTCATCTTGTCTACTGATGACCCTAACAAGGAAGACCCCCTTACTATCTGTCAAGAAATTGCTAGTCATATCAATCGTAAGGTTCGTATCATTATTGATCGAGAGGAAGCCATCAAAACAGCCATGTCTGAAACCACAGGATCAAGCGATGCCCTTGTTATCGCCGGTAAGGGAGCTGATGCCTTTCAAATTGTGAATGGTAAACGCACTGATTATGCTGGTGATATTGAAGTCGCTAAGAAATATTTGTAA

Protein sequence:

MITIEQVLEVLKKDHNFRDIINQEYYYYSWTGVTFDHLSYDSRDITPSTLFFAKGAGFKLEFLESAVQAGLGFYVAEKDYQVGIPAILVSDIKQAMSLVAQAFYQHPQDKLKLLAFTGTKGKTTASYFAFNILKQSHKPAMLSTMNTTLDGKTFFKSNLTTPESLDLFRMMAEAVSNGMTHLIMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLLKNSQAVIVNSGMNHFDFVAEEVADKDHDFYGKDSENTVKHSSGFSFKAKGKLAGDYDIQLIGDFNQDNAMAAGLACLRLGASLEDIKKGIAQTSVPGRMEILTQANGAKVFVDYAHNGDSLDKLLQVVTDHQKGKISLILGAPGNKGESRRQDFGHVLNTYPEINVILSTDDPNKEDPLTICQEIASHINRKVRIIIDREEAIKTAMSETTGSSDALVIAGKGADAFQIVNGKRTDYAGDIEVAKKYL

GenBank Info

locus_tag - FAM13496-i1-1.1_001328
EC_number - 6.3.2.7
inference - COORDINATES: similar to AA sequence:RefSeq:WP_013990079.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase
protein_id - extdb:FAM13496-i1-1.1_001328

Gene Locus

Located on scaffold FAM13496-i1-1_scf18

FAM13496-i1-1.1_001327
FAM13496-i1-1.1_001329